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secobarbital will reduce the extent or effect of felodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.secobarbital will reduce the level or effect of darifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.secobarbital will minimize the level or effect of atorvastatin by impactin